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GLP-1 projections from NTS to NAc and VTA promote satiation and reduce food reward, while orexinergic projection from lateral hypothalamus to NTS suppresses satiation and increases food reward ( The paraventricular thalamic nucleus (PVT) neurons receive GLP-1 innervation from NTS and express GLP-1R ( Telencephalon Moderate density of GLP-1R is expressed in both the cell bodies and fibers of the NAc shell and core ( Morphological studies revealed that the neurons in the bed nucleus of the stria terminalis (BNST) express a high level of GLP-1R ( Inconsistent distribution patterns of GLP-1R in the hippocampus have been reported by different morphological studies ( in vivo electrophysiological recordings showed that juxtacellular application of the active fragment of GLP-1, GLP-1 (7–36) amide induces an increase and then a decrease of firing activity in the hippocampal CA1 neurons

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doi: 10.1007/s00441-007-0413-7